Researchers at the National Cancer Research Centre (CNIO) have shown that partial pharmacological inhibition of PI3K enzyme reduces body weight and physiological manifestations of metabolic syndrome, particulary in diabetes and hepatic steatosis (fatty liver). This experiment was conducted with obese mice and monkeys, which showed no side effects or toxicity. The PI3K enzyme is responsible for achieving balance in the production of cellular and biochemical components of cell nutrients spending. The enzime favors and induces cell division and growth and ultimately can cause cancer. That is why many cancer researchers have worked with the intention of finding a drug that inhibits this enzyme to find a treatment for cancer.
To test the effect of this enzyme the researchers administered small samples of inhibitor CNIO-PI3ki to obese mice over a period of five months. After two months, the mice had lost 20% of their body mass. Afterwards their weight remained stable, following a high-fat diet. Another effect was the improvement of physiological symptoms and hepatic steatosis. Elena Lopez, from CNIO, explains that steady weight loss is very dangerous in obesity cases, so it is expected to achieve an alteration in the balance between undertaking and spending of nutrient, favoring the spending of energy.
If through more research, they are able to find a way to alter the balance of nutrients encouraging spending, it will be of great help to the obesity problem which most of the Americans face. This problem is due to several factors, one being genetic heritage. It is often difficult to work with and achieve a decrease in obesity because the body needs to store nutrients. That is why this treatment would be of great impact, because there are many people who will benefit from it. Furthermore, not only obesity reduces, this will reduce diabetes. This is a disease that just like obesity, affects a large portion of the American population. It is caused when the body can not regulate sugar levels in the blood, which is treated with a strict and rigid diet. There are three types of diabetes: diabetes type I, diabetes type II and gestational diabetes, which have very harmful effects on the health of the individual. Type I diabetes can not be prevented, however, type II diabetes can be prevented or delayed if you have a healthy diet and active lifestyle.For the previously mentioned reasons and many others, we hope we can find an efficient treatment for reducing obesity among the population. Like diabetes there are many more diseases that are caused by obesity. Meanwhile we should promote the correct nutrition in the busy lifestyle of people, since malnutrition has a big effect due to the time factor.
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